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Scientists have just lately discovered and succeeded in synthesizing conolidine, a purely natural compound that exhibits promise like a potent analgesic agent with a more favorable safety profile. Even though the specific mechanism of action continues to be elusive, it is actually at present postulated that conolidine may have many biologic targets

Importantly, these receptors ended up located to are actually activated by an array of endogenous opioids at a concentration similar to that noticed for activation and signaling of classical opiate receptors. Consequently, these receptors ended up identified to obtain scavenging exercise, binding to and reducing endogenous amounts of opiates obtain